The English verb 'go' comes with many, many meanings, especially in phrasal verbs. When translating into American Sign Language, there are many expressions.
There are a few or more signs for "GO" in ASL, depending on the sentences.
Meaning: To move from one place or point to another; travel.
Pronunciation (sign description): Two upright "1" (or index finger) hands apart in space in front of signer moves forward. This two-handed version is a citation in general. In everyday conversions, it's not common to see the one-handed version.
This GO-to verb is highly inflected in sentences. Often used with one hand.
Pronunciation (sign description): Two downright "1" hands apart in front of signer moves forward. If one-handed version is used, it changes a tone.
This one is less commonly used. In the 1980s where ASL learning emerged into popularity, this variation is one of some specific signs that ordinary Deaf signers teach hearing friends that they themselves don't use them. Why? There is a cultural-linguistic phenomenon for it.
Semantic variation.
Meaning: To leave; depart.
Usage examples: "Thanks for the lovely chat. I got to go now."
LEAVE, DEPART, MOVE, TRAVEL, en masse.
Opposite: COME.
go after: to pursue someone or something; try to catch or stop someone. See PURSUE, CHASE, FOLLOW.
go against: to oppose or resist something. See one of some synonyms: OPPOSE, DISAGREE.
First 100 words.
As you feel more comfortable with the first few hundreds of ASL signs, progress further with your vocabulary and learn signing more.